Hyperdilute Radiesse
A biostimulatory injectable treatment using calcium hydroxylapatite (CaHA) microspheres that has been diluted to shift its primary purpose from volumisation to collagen stimulation. When diluted, Radiesse spreads through the tissue and stimulates your body's own collagen production for gradual skin firming and quality improvement on the face, neck, décolletage and hands. Performed by an RGN-led medical aesthetics clinic.
What Is Hyperdilute Radiesse?
Hyperdilute Radiesse is an injectable biostimulator based on calcium hydroxylapatite (CaHA) microspheres — a biocompatible, biodegradable compound that has been used in aesthetic medicine for many years. In its standard formulation, Radiesse is used as a volumising filler for specific licensed facial indications. However, when Radiesse is diluted with sterile water (and often lidocaine for comfort), its behaviour and purpose change fundamentally. Dilution reduces the concentration of CaHA microspheres and changes the rheology of the product. Instead of sitting in one place to provide volumisation, diluted Radiesse spreads more broadly through the tissue. The CaHA microspheres act as a scaffold, triggering a localised wound-healing response that activates fibroblasts and stimulates new collagen production over weeks to months. The microspheres are gradually absorbed by the body as they are replaced by your own collagen. This means that while standard Radiesse is a volumising filler, Hyperdilute Radiesse is a collagen biostimulator — used for skin firming, quality improvement and tightening rather than for adding volume. It is particularly useful for areas where skin quality and laxity are the primary concern rather than volume loss, such as the neck, décolletage and backs of the hands. Hyperdilute Radiesse sits within ReGen's regenerative aesthetics pillar alongside Sculptra, Profhilo, Profhilo Structura, polynucleotides and skin boosters. Every treatment begins with a personalised medical consultation to assess your concerns, confirm suitability and develop an appropriate treatment plan.
Key Benefits
- Stimulates your own collagen — CaHA microspheres trigger natural collagen production — the result is your body's own tissue, not foreign product.
- Dual-action effect — Provides an immediate scaffolding effect from the gel carrier, then gradual collagen production as the microspheres are absorbed.
- Improves skin firmness — New collagen firms and thickens the skin, improving texture and resilience.
- Versatile across areas — Suitable for the face, neck, décolletage and hands — areas where traditional fillers are less appropriate.
- Gradual, natural-looking results — Improvement develops over weeks, avoiding an obvious 'done' look.
- Long-lasting — Results can last up to 12–18 months or more — longer than typical hyaluronic acid skin treatments.
- No animal-derived ingredients — CaHA is a synthetic, biocompatible compound — suitable for those who prefer non-animal products.
- Cumulative across a course — Each session builds on the last for progressive, natural improvement.
Is Hyperdilute Radiesse Right for You?
- Healthy adults over 18 seeking gradual skin firming and quality improvement rather than volumisation
- Patients with skin laxity, crepiness or thinning on the face, neck, décolletage or hands
- Those who prefer a biostimulatory approach that builds their own collagen over time
- Patients who understand that results develop gradually over weeks and cannot be dissolved like hyaluronic acid fillers
- Those with realistic expectations — an initial course of typically 2–3 sessions is required for optimal results
- Patients seeking long-lasting results — up to 12–18 months or more following a completed course
- Those who prefer a non-animal, synthetic biocompatible product
- Patients wanting to address areas such as the neck, décolletage or hands where traditional fillers are less suitable
What Can Hyperdilute Radiesse Treat?
Face — Lower Face & Jawline (Licensed / Off-Label)
Improvement of skin quality and mild laxity in the lower face and jawline. Some facial indications are licensed for standard Radiesse; hyperdilute use is off-label clinical practice.
Neck (Off-Label)
Skin firming and quality improvement on the neck, where skin laxity and crepiness are common concerns. Off-label use.
Décolletage (Off-Label)
Improvement of skin quality and fine wrinkling on the chest. Off-label use.
Backs of the Hands (Off-Label)
Skin thickening and quality improvement on the backs of the hands, where skin thinning is a common concern. Off-label use.
Selected Body Areas (Off-Label)
Skin quality improvement on selected body areas such as the abdomen (post-pregnancy laxity), knees or arms may be discussed where clinically appropriate. Off-label use.
Your Hyperdilute Radiesse Journey
Personalised Medical Consultation
30–45 minA personalised consultation includes a review of your medical history — including autoimmune conditions, allergies, previous treatments, medications and calcium metabolism disorders. Your skin quality and laxity are assessed across the areas of concern. Expectations are discussed openly: Hyperdilute Radiesse delivers gradual improvement over weeks, not instant change. Your suitability is confirmed and a treatment plan is created including session count, treatment areas and the dilution protocol. The licensed and off-label nature of each proposed treatment area is clearly explained.
Preparation
20–30 minOn the day of treatment, the skin is cleansed and disinfected. Radiesse is reconstituted with sterile water and lidocaine according to the hyperdilute protocol, with the dilution ratio adjusted for the treatment area. A topical numbing cream may be applied. The treatment areas are marked.
Treatment
30–45 minHyperdilute Radiesse is injected into the dermis or subcutaneous layer using a fine needle or cannula, depending on the treatment area. The diluted product spreads through the tissue, depositing CaHA microspheres to stimulate collagen production over the coming weeks. A full treatment session typically takes 30–45 minutes depending on the number of areas treated. You may feel mild pressure or a dull sensation during injection. The treated areas are massaged gently to ensure even distribution.
Review & Next Sessions
15–20 minA review appointment is scheduled at 4–6 weeks to assess your response. Because Hyperdilute Radiesse works gradually, subsequent sessions are spaced 4–6 weeks apart to allow collagen development to progress between treatments. A typical course is 2–3 sessions. Following the completed course, a maintenance assessment is scheduled at 6–12 months, with results commonly lasting 12–18 months or more.
About Hyperdilute Radiesse (CaHA)
Calcium Hydroxylapatite (CaHA) — Diluted
Hyperdilute Radiesse is based on calcium hydroxylapatite (CaHA) microspheres — a biocompatible and biodegradable synthetic compound that has been used safely in aesthetic medicine for many years. In its standard formulation, Radiesse is used as a volumising filler for specific licensed facial indications. When diluted with sterile water (and often lidocaine), the concentration of CaHA microspheres is reduced and the product spreads more broadly through the tissue, shifting its primary purpose from volumisation to collagen stimulation. The CaHA microspheres act as a scaffold within the dermis or subcutaneous layer, triggering a localised healing response that activates fibroblasts and stimulates new collagen production over weeks to months. The microspheres are gradually absorbed by the body as they are replaced by your own collagen. Diluted Radiesse contains no animal-derived ingredients.
When Will I See Results?
Hyperdilute Radiesse delivers gradual, natural results. Immediately after treatment, you may notice some improvement from the gel carrier and the presence of fluid, but this is temporary and subsides within a few days. This is not the true result. True results develop over 4–12 weeks as your body responds to the CaHA microspheres by producing new collagen. The skin gradually firms, thickens and improves in quality — naturally and subtly. Most visible improvement is seen after the full initial course, typically 2–3 sessions spaced 4–6 weeks apart. Results are cumulative — each session builds on the collagen produced by the previous one. Following a completed course, results are commonly maintained for 12–18 months or more — longer than typical hyaluronic acid skin treatments. This longevity is because the result is your own collagen, which persists long after the CaHA microspheres have been absorbed. Individual results vary based on age, skin condition, lifestyle and individual collagen response. Your clinician will discuss personalised expectations at your consultation.
Downtime & Recovery
Hyperdilute Radiesse involves minimal downtime. Mild swelling, redness and tenderness at the injection sites are common and typically resolve within 24–72 hours. Bruising is possible, particularly on delicate areas such as the neck or décolletage. Small palpable bumps under the skin may be felt initially as the microspheres settle — these usually resolve with massage. Most patients resume normal activities the next day. Makeup should be avoided for 24 hours. The immediate improvement visible after treatment is from the gel carrier and fluid, and will subside within a few days — this is expected and not a sign the treatment has not worked.
Risks & Contraindications
CONTRAINDICATIONS
- Pregnancy or breastfeeding
- Active skin infection in the treatment area
- Known hypersensitivity or allergy to any component of Radiesse (including CaHA, lidocaine or carboxymethylcellulose)
- Certain autoimmune or connective tissue conditions (assessed case by case at consultation)
- History of keloid or hypertrophic scarring
- Active cystic acne or severe inflammation in the treatment zone
- Bleeding disorders or use of anticoagulant therapy (assessed at consultation)
- History of severe allergic reactions (anaphylaxis)
POTENTIAL RISKS
- Mild swelling, redness, tenderness or bruising at injection sites (common, temporary — typically 24–72 hours)
- Palpable or visible bumps under the skin (possible; mitigated by post-treatment massage and correct injection technique)
- Nodule or granuloma formation (rare; mitigated by correct dilution, depth and technique)
- Variable results (individual collagen response differs from person to person)
- Discomfort during injection (minimised with lidocaine in the mixture)
- Asymmetry or uneven response (managed through course planning and review)
- Because Hyperdilute Radiesse stimulates your own collagen, results cannot be dissolved like hyaluronic acid fillers — this is why correct technique and candidate selection are essential
Hyperdilute Radiesse Aftercare
- Gently massage the treated areas for several minutes, 2–3 times a day, for 3–5 days to support even distribution of the product
- Avoid intense exercise, saunas and hot showers for 24–48 hours
- Avoid makeup for 24 hours
- Avoid direct sun exposure and use SPF 30+ daily
- Avoid alcohol for 24 hours
- Do not touch or rub the treated area excessively beyond the prescribed massage
- Stay well hydrated to support the healing and collagen production process
- Gentle skincare only for 48 hours — no active ingredients (retinol, acids, vitamin C)
- Attend your scheduled review appointments — follow-up sessions are essential to build cumulative results
- Contact the clinic if you notice persistent lumps, nodules or any concerns during the settling period
Frequently Asked Questions
Hyperdilute Radiesse is an injectable biostimulator based on calcium hydroxylapatite (CaHA) microspheres. When Radiesse is diluted with sterile water, its behaviour changes — instead of providing volumisation, the diluted product spreads through the tissue where the CaHA microspheres act as a scaffold, triggering your body's natural healing response and stimulating new collagen production. Over weeks to months, the skin gradually firms, thickens and improves in quality.
In its standard formulation, Radiesse is used as a volumising filler for specific licensed facial indications — the CaHA microspheres sit in one place and provide volume. When diluted, the concentration of CaHA is reduced and the product spreads more broadly through the tissue. The microspheres then act primarily as a collagen-stimulating scaffold rather than a volumising agent. This shifts the treatment's purpose from volumisation to skin firming and quality improvement, making it suitable for areas such as the neck, décolletage and hands.
Calcium hydroxylapatite has been used in aesthetic medicine for many years and has an established safety profile. When diluted and injected by a trained clinician using correct technique, dilution and depth, Hyperdilute Radiesse is considered a safe treatment. A thorough pre-treatment assessment and adherence to the post-treatment massage protocol minimise the risk of complications. Your suitability is confirmed at a medical consultation before any treatment begins.
Standard Radiesse uses the full concentration of CaHA microspheres to provide volumisation for specific licensed facial indications. Hyperdilute Radiesse dilutes the product with sterile water, reducing the CaHA concentration and changing its behaviour so it spreads through the tissue and acts primarily as a collagen stimulator. Standard Radiesse adds volume; Hyperdilute Radiesse improves skin firmness and quality. They serve different purposes and are used for different concerns.
Both are biostimulators, but they use different active ingredients. Hyperdilute Radiesse uses calcium hydroxylapatite (CaHA) microspheres, which provide an immediate scaffolding effect from the gel carrier and then stimulate collagen. Sculptra uses poly-L-lactic acid (PLLA), which stimulates collagen gradually over weeks with no immediate carrier effect. Both deliver gradual, natural results and last longer than hyaluronic acid treatments. Your clinician will advise which biostimulator is most appropriate for your individual concerns and anatomy.
Profhilo uses ultra-high concentration hybrid hyaluronic acid to improve skin laxity and firmness through hydration and tissue remodelling. Hyperdilute Radiesse uses calcium hydroxylapatite microspheres to stimulate collagen production through a scaffolding mechanism. Both are biostimulatory and address skin quality, but they work through different mechanisms. Your clinician will advise which is most appropriate for your concerns.
Profhilo Structura uses hybrid hyaluronic acid placed in the deep subcutaneous compartments to provide structural support and biostimulation. Hyperdilute Radiesse uses calcium hydroxylapatite microspheres to stimulate collagen through a scaffolding effect in the dermis or subcutaneous layer. Both target deeper concerns, but Profhilo Structura focuses on structural support while Hyperdilute Radiesse focuses on skin firming and quality. Your clinician will advise which is most appropriate.
Skin boosters deliver hyaluronic acid and nutrient complexes through micro-injections to improve hydration, luminosity and surface skin quality. Hyperdilute Radiesse uses calcium hydroxylapatite microspheres to stimulate collagen production, providing deeper skin firming and quality improvement. If your primary concern is dehydration or dullness, skin boosters are likely more appropriate. If your concern is skin laxity or thinning, Hyperdilute Radiesse may be more suitable. Your clinician will advise.
Polynucleotides are injectable treatments using purified DNA fragments to stimulate tissue regeneration at a cellular level, with a strong focus on skin quality, texture and delicate areas such as the under-eye. Hyperdilute Radiesse uses calcium hydroxylapatite microspheres to stimulate collagen through a scaffolding mechanism, providing skin firming and quality improvement. Both are regenerative, but they work through different mechanisms. Your clinician will advise which — or which combination — is most appropriate.
Hyperdilute Radiesse can be used on the face (particularly the lower face and jawline), neck, décolletage and backs of the hands. Treatment of the neck, décolletage, hands and body is off-label, meaning it is not within the product's licensed indications but may be used by a clinician where they judge it clinically appropriate. The licensed and off-label nature of each proposed treatment area is clearly explained at your consultation.
Off-label use means a treatment is used for an indication, area or dilution that is not included in the product's official licence. This is common and legal in medical and aesthetic practice — a clinician may use a product off-label where they judge it to be in the patient's best interests, based on their clinical knowledge and evidence. Off-label use is always discussed openly with you at consultation so you can make an informed decision.
Typically an initial course of 2–3 sessions, spaced 4–6 weeks apart, is recommended for optimal results. The exact number depends on the degree of skin laxity and your individual collagen response. Maintenance treatments may be recommended every 6–12 months to sustain results. Your personalised plan is confirmed at consultation.
Hyperdilute Radiesse delivers gradual results. Immediately after treatment you may notice some improvement, but this is from the gel carrier and fluid and subsides within days — it is not the true result. Real results develop over 4–12 weeks as new collagen is produced. Most visible improvement is seen after the full course of 2–3 sessions. Results are cumulative and natural-looking.
Following a completed course, results commonly last 12–18 months or more — longer than typical hyaluronic acid skin treatments. This is because the result is your own collagen, which persists long after the CaHA microspheres have been absorbed. Individual results vary. Maintenance treatments may be recommended every 6–12 months to sustain results.
Discomfort is minimal. Radiesse is diluted with sterile water and often lidocaine (a local anaesthetic) to improve comfort during injection. A topical numbing cream may also be applied. Most patients describe the sensation as mild pressure or a dull feeling rather than sharp pain.
No. Unlike hyaluronic acid fillers, which can be dissolved with an enzyme called hyaluronidase, Hyperdilute Radiesse cannot be reversed because the result is your own collagen, not a dissolvable product. This is why correct technique, careful candidate selection and realistic expectations are essential before treatment. Your clinician will discuss this openly at your consultation.
Yes. Hyperdilute Radiesse is not suitable during pregnancy or breastfeeding, for those with active skin infections in the treatment area, known allergy to any component of Radiesse, certain autoimmune or connective tissue conditions, a history of keloid scarring, active cystic acne in the treatment zone, bleeding disorders, or a history of severe allergic reactions. Your suitability is confirmed at consultation.
Yes — ReGen Aesthetics Clinic in Merthyr Tydfil is easily accessible from Cardiff, Pontypridd, Aberdare and across South Wales.
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Why Choose ReGen Aesthetics Clinic
Medical-Led Care
Every treatment is delivered within a clinical framework at an RGN-led medical aesthetics clinic, with your safety and wellbeing as the priority.
Registered Nurse
Treatments are performed by a fully registered, certified and insured aesthetic nurse.
Personalised Treatment Plans
No two faces are the same — your session count, treatment areas and dilution protocol are built around your unique anatomy and goals.
Natural-Looking Results
The aim is to stimulate your own collagen subtly and gradually, never to over-treat or change how you look.
Evidence-Based Practice
Treatment decisions are grounded in clinical evidence and established aesthetic principles.
Ongoing Aftercare & Support
Your journey includes follow-up reviews and continued support throughout the treatment course and beyond.
Every Hyperdilute Radiesse treatment begins with a personalised medical consultation at our RGN-led medical aesthetics clinic to assess your skin quality, review your medical history and confirm suitability — including an open discussion of licensed and off-label treatment areas, expected results and the recommended course.