Polynucleotides
Healthier, smoother, more renewed skin through regenerative skin repair. Polynucleotides deliver purified DNA fragments that stimulate the skin's own tissue repair processes, improving dark circles, crepiness and skin quality. Each treatment is tailored to your individual concerns and goals for natural, gradual improvement — not volume, not a treated face.
What Are Polynucleotides?
Polynucleotides are a regenerative injectable — a category distinct from skin boosters, Profhilo and dermal fillers. They are made from purified DNA fragments, naturally occurring building blocks that support the skin's repair processes. Rather than adding volume or hydrating the surface, polynucleotides stimulate tissue repair and regeneration at a cellular level — supporting fibroblast activity, collagen production and skin renewal. The result is improved skin quality, texture and renewal over weeks, particularly effective for concerns like under-eye dark circles, crepey skin and areas of skin damage. Suitable for the face, periorbital (under-eye) area, neck, décolletage, hands and other areas where skin repair is needed, polynucleotides are particularly valued for the periorbital area, where thin, crepey or dark-circle-prone skin may benefit from regeneration. They may also improve the appearance of certain acne scars as part of a comprehensive treatment plan. Every treatment begins with a personalised medical consultation.
Key Benefits
- Regenerates skin tissue — Stimulates the skin's own repair processes — supporting fibroblast activity and collagen production for genuinely renewed skin.
- Improves under-eye dark circles — Particularly effective for the periorbital (under-eye) area — addresses thin, crepey skin and dark circles.
- Smooths crepey skin — Improves skin quality in delicate areas — under eyes, neck, décolletage and hands — where skin has become thin or crepey.
- May improve certain acne scars — May improve the appearance of certain acne scars as part of a comprehensive treatment plan.
- Natural, gradual improvement — Results develop over weeks as the skin renews — the change looks like healthier skin, not a treated face.
- No facial volume change — Unlike dermal fillers, polynucleotides do not add volume — they improve skin quality through regeneration.
- Versatile treatment areas — Can treat face, periorbital (under-eye) area, neck, décolletage, hands and other areas where skin repair is needed.
- Biocompatible and well-established — Polynucleotide treatments have a well-established safety profile and are biocompatible with the skin's natural processes.
Are Polynucleotides Right for You?
- Individuals concerned about under-eye dark circles caused by thin or crepey skin
- Those with crepey skin on the face, neck, décolletage or hands
- Patients wanting to improve skin quality and texture through regeneration rather than hydration or volume
- Those with certain acne scars or textural irregularity seeking skin renewal support as part of a comprehensive plan
- People who feel skin boosters or Profhilo alone are insufficient for their degree of skin damage or dark circles
- Patients seeking a regenerative approach to skin ageing
- Individuals with realistic expectations — gradual improvement over weeks, not immediate transformation
- Those wanting to treat areas where volume-adding treatments may not be the most appropriate first approach (periorbital, neck, hands)
- Patients who understand that 2–3 sessions are typically required for optimal results
Areas Polynucleotides Can Treat
Periorbital (Under-Eye) Rejuvenation
Signature area — dark circles, tear trough skin quality, thin crepey under-eye skin.
Face
Overall skin quality, texture renewal.
Neck
Crepey skin, horizontal neck lines, skin renewal.
Décolletage
Wrinkles and skin quality on the chest area.
Hands
Ageing skin on the backs of the hands.
Scalp / Hair
Scalp skin health (where offered).
Stretch marks / Scars
Areas of skin damage or scarring where regeneration may be beneficial as part of a comprehensive plan.
Your Polynucleotides Treatment Journey
Consultation & Planning
20–30 minA personalised medical consultation includes an assessment of your skin concerns, goals and medical history. Treatment areas are mapped. The appropriate product is selected (e.g. Plinest vs Plinest Eye based on area). The protocol of 2–3 sessions is explained. Photographs may be taken for reference.
Preparation
15–20 minOn the day of treatment, the skin is cleansed thoroughly and a topical numbing cream is applied for comfort. The treatment area is marked. The periorbital (under-eye) area requires particularly precise marking.
Treatment
20–30 minA series of micro-injections deliver the polynucleotide product into the superficial to mid-dermis across the treatment area. Periorbital treatments use a specialised technique with very small amounts of product placed precisely.
Review & Aftercare
10 minImmediate aftercare instructions are provided. Your next session is scheduled — typically 2–3 weeks apart. A maintenance plan is discussed. Your skin's response is reviewed at follow-up.
Products Used
Plinest
A polynucleotide injectable treatment made from purified DNA fragments. Designed to stimulate tissue repair and regeneration at a cellular level, supporting fibroblast activity, collagen production and skin renewal. Suited to face, neck, décolletage, hands and areas of skin damage or scarring.
Plinest Eye
A specialised polynucleotide formulation designed specifically for the delicate periorbital (under-eye) area. Delivered through a precise micro-injection technique to improve thin, crepey under-eye skin, dark circles and skin quality.
Results & Longevity
Results are gradual — polynucleotides work by stimulating the skin's own repair processes, so improvement develops over weeks. Initial improvement in skin texture may be noticeable within 2–3 weeks. Collagen production and tissue regeneration continue over 4–8 weeks, with the full effect developing over the course of the treatment protocol. Regeneration is a cumulative process. The first session initiates the skin's repair response; subsequent sessions build on and reinforce that response, layering improvement. For most concerns, an initial course of 2–3 sessions (spaced 2–3 weeks apart) produces optimal results. Following the initial course, maintenance treatments every 4–6 months sustain results. Because every person's skin and metabolism differ, longevity varies — your clinician will discuss personalised expectations at consultation.
Downtime & Recovery
Polynucleotides involve minimal downtime. Small bumps at injection sites are common and typically resolve within a few hours. Mild redness is expected and usually settles within 24 hours. Periorbital (under-eye) treatments may cause mild swelling for 1–2 days. Bruising is possible, particularly in the periorbital area where skin is delicate. Most people return to normal activities the same day, though makeup and strenuous exercise are best avoided for 24 hours.
Risks & Contraindications
CONTRAINDICATIONS
- Pregnancy or breastfeeding
- Active infection or inflammation in the treatment area
- Known allergy to any product component
- Blood clotting disorders or use of blood-thinning medication
- Autoimmune conditions (assessed case by case)
- Active cold sores in the treatment area
- Certain medications (discuss at consultation)
POTENTIAL RISKS
- Mild swelling, redness or tenderness at injection sites
- Bruising (more common in the periorbital area)
- Small bumps (typically resolve within hours)
- Temporary unevenness during the settling period
- Allergic reaction (rare)
- Incomplete result or need for additional sessions (addressed in the protocol)
- Infection (rare; mitigated by aseptic clinical technique)
Aftercare Guidance
- Avoid touching, rubbing or massaging the treated areas for 24 hours
- Avoid strenuous exercise for 24 hours
- Avoid alcohol for 24 hours
- Avoid excessive heat (saunas, hot baths, sun exposure) for 48 hours
- Avoid applying makeup for 12–24 hours
- Avoid facial treatments (facials, peels, massages, laser) for 72 hours
- Stay hydrated and drink plenty of water
- Use gentle skincare and SPF daily
- Attend your follow-up sessions — the initial course is important for building results
- Attend your maintenance review — typically scheduled 4–6 months after completing the initial course
- Contact the clinic if you have any concerns during the settling period
Frequently Asked Questions
An initial course of 2–3 sessions, spaced 2–3 weeks apart, is typically recommended. Maintenance treatments every 4–6 months then sustain results. Your personalised plan is confirmed at consultation.
Results are gradual. Initial improvement may be noticeable within 2–3 weeks, with the full effect developing over 4–8 weeks as collagen production and tissue regeneration increase.
Results vary by individual. They are commonly maintained for around 4–6 months, with maintenance treatments recommended to sustain improvement. Your clinician will discuss realistic expectations tailored to your case during your consultation.
Most patients report minimal discomfort. A topical numbing cream is applied beforehand. The periorbital area is delicate but well-tolerated, and sensation is typically described as mild pressure rather than pain.
Profhilo is HA-based bio-remodelling for skin laxity. Polynucleotides are DNA-fragment-based regeneration for tissue repair — particularly for under-eye dark circles, crepiness and skin renewal. If your concern is laxity or loss of firmness, Profhilo may be more suitable. If your concern is dark circles, crepiness or skin repair, polynucleotides may be more appropriate. Your clinician will advise.
Skin boosters deliver hyaluronic acid and nutrients for surface hydration. Polynucleotides stimulate deeper tissue repair and regeneration. If your concern is dehydration or dullness, skin boosters are likely more appropriate. If your concern is dark circles, crepiness or skin repair, polynucleotides may be more suitable.
Dermal fillers add volume and structure. Polynucleotides do not add volume — they regenerate skin quality. For some patients with thin, crepey under-eye skin, regenerative treatments may be more appropriate as a first approach; for others, fillers may still be suitable. Your clinician will advise based on your individual anatomy.
Polynucleotides are purified DNA fragments — naturally occurring building blocks that are already present in your body. When used as an injectable treatment, they support the skin's own repair processes, helping it to renew and regenerate from within.
When injected into the skin, polynucleotides stimulate fibroblast activity — the cells responsible for producing collagen and the structural components of healthy skin. They also support tissue repair and regeneration at a cellular level. The result is gradually improved skin quality, texture and renewal over weeks, as the skin rebuilds itself.
Under-eye dark circles are often caused by thin, crepey skin. Polynucleotides regenerate the skin itself, improving its thickness and quality without adding volume. For some patients with thin, crepey under-eye skin, this regenerative approach may be more appropriate than a volume-adding treatment. For others, dermal fillers may still be suitable. Your clinician will advise based on your individual anatomy.
Polynucleotides may improve the appearance of certain acne scars as part of a comprehensive treatment plan. They are not a standalone solution for all acne scarring. Your clinician can advise whether they are appropriate for your specific concerns, often alongside other treatments.
Yes. Polynucleotides can complement Profhilo, skin boosters, dermal fillers, anti-wrinkle injections, microneedling and chemical peels as part of a comprehensive plan. Your clinician will advise on the most appropriate combination and sequencing for your goals.
Polynucleotides and microneedling may complement each other as part of a personalised treatment plan. However, the sequence and timing depend on your skin concerns and clinical assessment — they are not always performed at the same appointment. Your clinician will advise on the most appropriate sequencing based on your individual needs.
The periorbital (under-eye) area is the signature treatment area. Polynucleotides can also treat the face, neck, décolletage, hands, scalp and areas of scarring or stretch marks.
Yes. Polynucleotides are not suitable during pregnancy or breastfeeding, with active skin infection in the treatment area, or with known allergy to product components. They are also not designed for immediate or dramatic results, or for volume restoration. Your suitability is confirmed at consultation.
Yes. A personalised medical consultation is required before any treatment to assess your skin, confirm suitability and create an appropriate treatment plan.
Related Treatments
Why Choose ReGen Aesthetics Clinic
Medical-Led Care
Every treatment is delivered within a clinical framework at an RGN-led medical aesthetics clinic, with your safety and wellbeing as the priority.
Registered Nurse
Treatments are performed by a fully registered, certified and insured aesthetic nurse.
Personalised Treatment Plans
No two faces are the same — your plan is built around your unique skin and goals.
Natural-Looking Results
The aim is to enhance your skin subtly, never to over-treat or change how you look.
Evidence-Based Practice
Treatment decisions are grounded in clinical evidence and established aesthetic principles.
Ongoing Aftercare & Support
Your journey includes follow-up reviews and continued support throughout the treatment course and beyond.
Every polynucleotides treatment begins with a personalised medical consultation at our RGN-led medical aesthetics clinic to assess your skin, discuss your goals and confirm suitability.